An Outbreak of Endogenous Fungal Endophthalmitis Among Intravenous Drug Abusers in New England

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Retinal neovascularization and endogenous fungal endophthalmitis in intravenous drug users.

Intravenous (IV) heroin abuse in persons aged 12 has nearly doubled between the 2002 and 2012. Intravenous drug users (IVDU) are a high-risk group for developing endogenous fungal endophthalmitis (EFE), with Candida albicans being the most commonly identified causative organism. Endogenous fungal endophthalmitis is a potentially blinding disease in which the causative organism reaches the eye t...

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Treatment of endogenous fungal endophthalmitis: focus on new antifungal agents.

Endogenous fungal endophthalmitis, involving only the chorioretinal structures or extending to involve the vitreous (vitritis), is a sight-threatening infection requiring early appropriate therapy. Endophthalmitis is a relatively frequent complication of candidemia and less commonly occurs in patients who have invasive aspergillosis. Because the eye is a protected compartment, penetration of sy...

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Streptococcus anginosus-associated endogenous endophthalmitis mimicking fungal endophthalmitis.

Endogenous bacterial endophthalmitis (EE) is recognized as a major cause of visual loss with an associated mortality rate and is a diagnostic challenge in the early stages of the disease, with 16% to 63% of cases being initially misdiagnosed (T. L. Jackson, S. J. Eykyn, E. M. Graham, and M. R. Stanford, Surv. Ophthalmol. 48:403–423, 2003, and M. J. Greenwald, L. G. Wohl, and C. H. Sell, Surv. O...

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[Infectious endocarditis in intravenous drug abusers].

Clinical course of infectious endocarditis (IE) was analysed for 43 intravenous drug abusers. 42 of them had primary IE, one patient--secondary. Acute course and high activity of the disease were registered in 86% of the patients. IE was provoked by Staphylococcus aureus (50%), Staphylococcus epidermidis 920%), Staphylococcus haemolyticus (11%), E. coli (8%), Pseudomonas aeruginosa (2%), Candid...

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Endogenous Aspergillus endophthalmitis in a healthy individual.

BACKGROUND Fungal endogenous endophthalmitis in a healthy individual without any predisposing factors is very uncommon. It can occur in intravenous drug abusers, where Aspergillus is more frequently isolated as the causative organism. CASE We treated an unusual case of culture-proven endogenous Aspergillus endophthalmitis who was immunocompetent and was not an intravenous drug user. The affec...

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ژورنال

عنوان ژورنال: JAMA Ophthalmology

سال: 2017

ISSN: 2168-6165

DOI: 10.1001/jamaophthalmol.2017.0650